荣誉奖项（杜晓刚）

2、论文：
（1）Analysis of Traditional Chinese Medicine Symptoms in Children with Spastic Cerebral Palsy, a Protocol for Data Mining         
Xing Wang1,2 , Fang Pang3 , Xiao-Gang Du2       
1  M. Kandiah Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang, Selangor, Malaysia; 2 Famous TCM Expert Heritage  Studio, Xi’an Encephalopathy Hospital Affiliated to Shaanxi University of Chinese Medicine, Xi’an, Shaanxi, People’s Republic of China; 3 Institute of Sports Biology, Shaanxi Normal University, Xi’an, Shaanxi, People’s Republic of China Correspondence: Xiao-Gang Du, Famous TCM Expert Heritage Studio, Xi’an Encephalopathy Hospital Affiliated to Shaanxi University of Chinese Medicine, Xi’an, Shaanxi, People’s Republic of China, Email duxg198012@163.com

Background: Cerebral palsy (CP) is characterized by abnormal pronunciation, posture, and movement. Clinically, CP can becategorized into various motor syndromes, including spastic hemiplegia, diplegia, quadriplegia, involuntary movement, ataxia, and mixed types. Among these, spastic CP represents over 70–80% of all CP cases. The primary objective of our study is to identify thetop and core Traditional Chinese Medicine (TCM) symptoms and analysis their association rules in children with spastic cerebralpalsy, thereby enhancing the theoretical foundations of TCM treatment on spastic CP.Methods: The study will be conducted on children aged 4 to 14 years with spastic CP who are undergoing treatment at Xi’an EncephalopathyHospital Affiliated to Shaanxi University of Chinese Medicine. Basic information about the patients and their TCM symptoms will be collected on the first day of admission. This information will include age, gender, birth history, family history, disease classification, and TCM symptoms(including symptoms, tongue, and pulse). Once the data is collected, it will be exported from the electronic medical record system for further analysis. Descriptive statistics will be performed using Excel 2019, while exploratory factor analysis and cluster analysis will be conducted using SPSS Statistics 22. Additionally, association rule analysis will be carried out using SPSS Modeler 18. Results: This study will investigate the most top TCM symptoms in children with spastic CP and explore the association rulesbetween these symptoms, mapping the presentation of spastic CP onto symptoms identified within TCM. Conclusion: Our findings will provide the distinctive characteristics of TCM symptoms in children with spastic CP, furnishing evidence-based support to clinicians and patients in making well-informed decisions collaboratively.

Keywords: cerebral palsy, TCM symptoms, data mining, descriptive statistics, association rule analysis, exploratory factor analysis, cluster analysis



（2）Acupuncture and Tuina Treatment for Gross Motor Function in Children with Spastic Cerebral Palsy: A Monocentric Clinical Study

Xing Wang1,2  , Siew Hoon Teh1 , Xiao-Gang Du2 , Xing-Hua Wang1

1M. Kandiah Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang, SGR, Malaysia; 2 Famous TCM Expert Heritage Studio, Xi’an Encephalopathy Hospital Affiliated to Shaanxi University of Chinese Medicine, Xi’an, Shaanxi, People’s Republic of China Correspondence: Xing-Hua Wang, M. Kandiah Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang, Selangor, Malaysia,  Email wangxh@utar.edu.my

Objective: Cerebral palsy (CP) is a condition characterized by abnormal pronunciation, posture, and movement, particularly spastic CP, which involves Gross motor dysfunction due to increased muscle tone and stiffness. This monocentric clinical study aims to evaluate the effectiveness of acupuncture and tuina (AT) in improving gross motor function and alleviating associated symptoms in children diagnosed with spastic CP. Methods: A total of 83 eligible patients received AT treatment, while 85 patients received conventional rehabilitation treatment. Both groups underwent a 12-week treatment period following the research protocol. Pre- and post-treatment assessments included the Modified Ashworth Muscle Tension Scale (MAS), Gross Motor Function Measure (GMFM-D and GMFM-E), 6-min walking distance measurement (6MWD), and Modified Children’s Functional Independence Rating Scale (WeeFIM). Results: After 12 weeks of treatment, when compared with baseline, the scores of MAS in both AT group and control group are decreased (p<0.01, p<0.01), the scores of GMFM-D, GMFME, 6MWD, WeeFIM in both group are increased (p<0.01 in all indicators). When compared with control group, AT group had significantly lower MAS scores compared to the control group (p<0.01), indicating reduced muscle tension. Moreover, AT group showed significantly higher scores in GMFM-D, GMFM-E, 6MWD, and WeeFIM compared to the control group (p<0.01 in all indicators), indicating improved gross motor function and functional independence. The study also revealedaninverse correlation between the children’s age and treatment efficacy (r= −0.496, p<0.01 in AT group, r=−0.540, p<0.01 in control group), highlighting the importance of early intervention in the management of CP in children. Conclusion: These findings suggest that AT may effectively enhance gross motor function and alleviate associated symptoms in children diagnosed with spastic CP. Moreover, early initiation of treatment is crucial to maximize therapeutic efficacy in children with spastic CP. Trial Registration: Chinese Clinical Trial Registry, ChiCTR2200059823. Registered on 12 May 2022.

Keywords: acupuncture, cerebral palsy, modified Ashworth muscle tension scale, gross motor function, the 6-minute walking distance measurement, children’s functional Independence rating scale

Xing Wang1,2 , Fang Pang3 , Xiao-Gang Du2

1M. Kandiah Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang, Selangor, Malaysia; 2 Famous TCM Expert Heritage Studio, Xi’an Encephalopathy Hospital Affiliated to Shaanxi University of Chinese Medicine, Xi’an, Shaanxi, People’s Republic of China; 3 Institute of Sports Biology, Shaanxi Normal University, Xi’an, Shaanxi, People’s Republic of China Correspondence: Xiao-Gang Du, Famous TCM Expert Heritage Studio, Xi’an Encephalopathy Hospital Affiliated to Shaanxi University of Chinese Medicine, Xi’an, Shaanxi, People’s Republic of China, Email duxg198012@163.com

Background: Cerebral palsy (CP) ranks as a major cause of motor disabilities in children, with spastic CP making up roughly 70– 80% of all CP cases. The primary objective of our study is to identify characteristics of Traditional Chinese Medicine(TCM) symptom of spastic CP, thereby establishing correlations between the TCM symptom and the disease, providing a more scientific theoretical foundation for TCM treatments on spastic CP, enabling a deeper comprehension of clinical interventions, ultimately, improving rehabilitation outcomes in TCM treatment for spastic CP. Methods: We conducted a data mining study on TCM symptom of spastic CP children aged 4–14 years old treated at Xi’an Encephalopathy Hospital Affiliated to Shaanxi University of Chinese Medicine, from October 2021 to March 2023. The medical records of all eligible and complete spastic CP patients were extracted, processed for data cleansing, transformed, and subsequently analyzed to discern distinctive TCM symptom. K-Means Clustering Analysis and Association Rule Analysis were used for data mining. Results: Core symptoms identified for spastic CP encompassed “Motor Dysfunction”, “Impaired Speech”, “Delayed Development”, “Limb Stiffness”, “Rigidity in the limbs”, “Intellectual Impairment”, “Timidity and susceptibility to startle responses”, “Muscle Wasting”, and “Pale or Dull Complexion”. Among the top-ranking associations of symptom, patterns emerge wherein “Motor dysfunction” intertwine with “Impaired speech”, “Motor dysfunction” coexist with “Delayed development”, and “Impaired speech” are accompanied by “Delayed development”.

Conclusion: This study identified the core symptom of spastic CP and tentatively suggests that the clinical manifestations of spastic CP are essentially consistent with the TCM pattern “liver exuberance and spleen weakness”. This finding has facilitated the preliminary establishment of correlations between TCM pattern differentiation and the disease in medicine. It is anticipated thatthis correlation will bring tangible benefits to a larger number of children with spastic CP.

Keywords: spastic cerebral palsy, TCM symptom, data mining, R language



（4）中医儿科临床诊疗指南·孤独症谱系障碍

赵宁侠，宋虎杰，杜晓刚，高峰，樊亚妮，张倩，焦文涛，郭凯，张宁勃 （陕西中医药大学附属西安中医脑病医院，西安 710032）

摘要：通过文献检索、文献评价、文献研究总结、3轮专家问卷调查、专家论证会、专家质量方法学评价和临床一致性评价，制定《中医儿科临床诊疗指南·孤独症谱系障碍》。本指南提出了孤独症谱系障碍（ASD）的诊断、辨证、治疗、预防和调护建议，适用于18周岁以下人群孤独症谱系障碍的诊断和防治，适合中医科、儿科、精神科、心理科等相关临床医师使用。

关键词：中医儿科；临床诊疗指南；孤独症谱系障碍；标准化



（5）中医内科临床诊疗专家共识·脑积水（正常压力脑积水）

怡文辉１ ， 陈霄１∗ ， 王凯悦１ ， 魏建立１ ， 杜晓刚１ ， 张敏１ ， 刘海洋１ ， 宋虎杰１ ， 何丽云２ ，苏同生３ ， 林海４ ， 黄燕５ ， 王新志６ ， 赵建军７ ， 杨文明８ ， 汪振宇９ ， 陈建宗１０

（１． 西安中医脑病医院， 陕西 西安 ７１００３２； ２． 中国中医科学院， 北京 １００７００；３． 陕西省中医医院， 陕西 西安 ７１０００３； ４． 西安市中医医院， 陕西 西安 ７１００２１；５． 广东省中医院， 广东 广州 ５１０１２０； ６． 河南中医药大学第一附属医院， 河南 郑州 ４５００９９；７． 吉林省中医院， 吉林 长春 １３００２１； ８． 安徽省中医院， 安徽 合肥 ２３０００９；９． 营口市中医院， 辽宁 营口 １１５００２； １０． 西京医院， 陕西 西安 ７１００３２）

［摘要］ 正常压力脑积水（ｎｏｒｍａｌ ｐｒｅｓｓｕｒｅ ｈｙｄｒｏｃｅｐｈａｌｕｓ）患者，临床上虽脑脊液压力在正常范围内，但表现为临床“三联征”的综合征（步态不稳、痴呆、尿失禁），同时伴随脑室扩大。 目前，鉴于中医古籍中未有脑积水之病名，脑积水仅参见于中医“痴呆” “饮病”“头痛”“眩晕”等范畴，故正常压力脑积水尚无明确具体的中医病名，根据 ２０１０ 年国家中医药管理局重点专科协作组专家共识，以“脑积水”作为中医病名。 因此，我院集合领域内众专家学者，通过文献检索、文献评价、文献研究总结、３ 轮专家问卷调查、专家论证会、专家质量方法学评价和临床一致性评价，为加强脑积水（正常压力脑积水）患者的诊断和治疗，指导中医脑病科、神经内科等相关临床医师合理诊疗，特制定《中医内科临床诊疗专家共识·脑积水病（正常压力脑积水）》。 该共识明确了脑积水（正常压力脑积水）的疾病名称、范围、术语和定义、诊断、辨证、治疗、预防和调护建议，在中医药分证论治同时，推荐配合外治法、针灸、推拿、康复疗法、物理疗法等综合措施，旨在为进一步推动脑积水疾病中医临床诊疗水平、促进中医药标准化项目提供参考。

［关键词］ 中医内科；临床诊疗专家共识；正常压力脑积水



（6）某院 2018 ～ 2021 年医疗机构制剂使用情况分析

杜晓刚 1，2，卫向锋 1，2 ＊，崔妮 1，2，查炯林 1（1 西安中医脑病医院，西安 710032；2 西安市中药制剂工程技术研究中心，西安 710032）

【摘要】目的 探讨医疗机构制剂的发展方向，促进可持续发展。方法 通过医院信息管理系统，回顾性分析 2018 ～ 2021 年医疗机构制剂的生产使用情况，包括生产品种数量、总批次量、总销售量、总销售金额、使用量排序、用药金额排序，分析医疗机构制剂使用的倾向性。结果 4 年间，医疗机构制剂品种的生产配制与使用总体呈增长趋势，用药金额构成比逐年增加。结论 在现有制剂稳定生产的基础上，医院应加大成果转化力度，推动制剂从科研走向临床；充分发挥脑病医院特色及中药制剂优势，开发专科特色制剂；设立区域医疗机构制剂配制中心，保障医联体单位以及委托配制合作单位的临床用药需求；不断开发新制剂，弥补市售产品不足，实现医疗机构制剂的可持续发展。

【关键词】医疗机构制剂；脑病专科中药制剂；可持续发展


（7）避瘟解毒颗粒的组方论析

余春，卫向锋 * ，宋虎杰，李省让，闫炳苍，杜晓刚，张玲，余亚兰（西安中医脑病医院，陕西 西安，710032）