（1）A Case Report on Treating Progressive Supranuclear Palsy with a Combination of Chinese and Western Medicine
Abstract: A case of progressive supranuclear palsy in a 66-year-old woman is presented. The patient complained ofprogressive stiffness of both lower limbs for five years, accompanied by choking and coughing for more than 1 year,” andwas diagnosed with paralysis in traditional Chinese medicine (TCM), which was characterized by a deficiency of liver andkidney, and phlegm and blood stasisblocking the collaterals. Western medicine diagnosed it as progressive supranuclearpalsy. The patient was diagnosed with “Parkinson’s disease” several times in the past and was given “polybasic hydrazide”and “amantadine hydrochloride tablets,” etc. The patient did not have significant symptomatic relief, so she sought furthertreatment with a combination of traditional Chinese and Westernmedicine. Based on the concept of deficiency and excess,this disease is categorized as a paralytic disease in Chinese medicine, and the onset of the disease is closely related tothe deficiency of the body after a long period of illness, with wind, phlegm, blood stasis, and deficiency as the mainpathogenetic mechanism. The treatment is based on the combination of disease and evidence, with traditional Chinesemedicine and acupuncture as the main treatments, supplemented by intermediate-frequency pulsed electrical stimulation,transcranial repetitive magnetic stimulation, medicated canisters, wax therapy, traditional Chinese medicine guasha, andacupoint injections. Western medicine is based on symptomatic treatment, and the patient’s symptoms were relievedsignificantly after the combination of Chinese and Western medicine.
Keywords: Progressive supranuclear palsy; Paralytic disease; Diagnosis and treatment; Deficiency and excess;Combination of Chinese and Western medicine
（2）Clinical Study on Improving Articulation Clarityin Spastic Cerebral Palsy with 120 Cases ofOral-Facial Acupressure Combined with Oral Placement Therapy
Yongjie Gong1 , Kai Wu1 , Shan Yang1 , Yalan Yu2 *, Xiaobo Zhang2 , Fei Rong2 , Yuan He2
Abstract: Objective: To observe the efficacy of oral-facial acupressure combined with oral placement therapy (OPT) inimproving articulation clarity in 120 children with spastic cerebral palsy, and to explore effective therapeutic solutionsfor speech disorders associated with spastic cerebral palsy. Methods: A total of 120 children with spastic cerebral palsyand speech disorders, meeting theinclusion criteria, were randomly assigned into two groups: 60 cases in the treatmentgroup and 60 cases in the control group. The treatment group received orofacial acupressure combined with OPT, whilethe control group received only OPT. The Oral Motor Function Assessment Scale (OMFAS), developed by the ChinaRehabilitation Research Centre (CRRC), was used to evaluate the treatmentoutcomes before and after the intervention.Results: After the treatment, both the treatment and control groups showed improved mobility of the mandible, lips,and tongue. However, the treatment group exhibited significantly better improvement than the control group, with thedifference between the two groups being statistically significant (P < 0.05). Conclusion: Oral-facial acupressure combinedwith OPT can effectively improve articulation clarity in children with spastic cerebral palsy. This combined therapy isrecommended for clinical promotion and application.
Keywords: Oral-facial acupressure; Oral placement therapy (OPT); Speech disorders in children with spastic cerebralpalsy; Speech intelligibility
（3）Discussion on Traditional Chinese MedicineTreatment of Liver-Depression-Spleen-DeficiencyType Insomnia Based on the State-Target Theoryand the Regulation of Microbiome-Gut-Brain Axis
Kai Wu1 , Yongjie Gong1 , Shan Yang1 , Yalan Yu2 *
Abstract: Insomnia has become an urgent clinical problem in modern society. Current research has found that the gutflora-gut-brain axis plays an important role in regulating insomnia. The state-target theory is a product of the combinationof traditional Chinese medicine and modern molecular biology technology. This paper clarifies the correlation betweenthe state-target theory, the intestinalflora-gut-brain axis, and liver-depression-spleen-deficiency insomnia. The use oftraditional Chinese medicine to regulate the structure and abundance of intestinal flora was also explored, aiming tointegrate traditional Chinese medicine with Western medicine for the prevention and treatment of liver-depression-spleendeficiency insomnia.
Keywords: State-target theory; Microbiome-gut-brain axis; Liver-depression and spleen deficiency; Insomnia; TraditionalChinese medicine
（4）Research Progress and Mechanisms ofAcupuncture Combined with TranscutaneousVagal Nerve Stimulation in the Treatment ofCognitive Impairment after Stroke
Shan Yang 1 , Yongjie Gong1 , Kai Wu1 , Haoxing Lei1 , Yalan Yu 2 *
Abstract: Cognitive impairment is a common complication after stroke, which not only affects the rehabilitation process ofpatients but also increases the family and socio-economic burden. Finding an effective treatment for cognitive impairmentafter stroke is urgent. Acupuncture can effectively activate blood circulation, dredge collaterals, tonify qi and blood, andregulate yin and yang. It is an effective method for the treatment of cognitive impairment after stroke. Recent studies haveshown that acupuncture combined with various modern rehabilitation techniques, such as transcutaneous vagus nervestimulation, has better clinical effects than either acupuncture or rehabilitation therapy alone. This article reviews theclinical research and basic mechanisms in this field by searching Chinese and English literature from the past 20 years,aiming to provide research ideas for future studies on the combined treatment of post-stroke cognitive impairment andrelated mechanisms.
Keywords: Percutaneous vagal nerve stimulation; Cognitive impairment after stroke; Stroke; Acupuncture
（5）宋虎杰运用经方治疗脑病后多重耐药菌肺炎经验*
余亚兰，陈 霄，卓坤利
[摘要] 脑病后多重耐药菌感染性肺炎，不仅影响患者康复效果，重则危及生命，如何予以有效治疗具有积极意义。宋虎杰教授根据“肺与大肠相表里”理论，提出了“通腑泻肺法”，临床时应用柴胡剂、承气汤类方、白虎汤方等经方论治阳热证，使腑气通利，肺热随之下泄，则喘满、咳嗽自除，疗效显著。附验案2则以佐证。
[关键词] 脑病；多重耐药菌肺炎；柴胡汤；白虎汤；承气汤；通腑泻肺；经方治疗；宋虎杰；名医经验
3、项目
（1）第二批省级中医药中青年科技骨干人才项目
（2）一种基于迷走神经调节治疗失眠的仪器转化研究
（3）北京中医药大学东直门医院临床研究和成果转化能力提升试点项目合作实施协议
（4）基于神经-血管-肌群耦合分析的脑卒中上肢运动功能评估及rTMS干预机制研究
